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The peptides defined amino acid sequence and consistent analytical characteristics have contributed to its popularity within peptide research and laboratory-based investigations

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Angiogenesis 21:711724

IL-6 can sensitize nociceptors directly, leading to mechanical allodynia (pain from typically non-painful stimuli) and thermal hyperalgesia (increased sensitivity to pain from heat or cold) (Sebba, 2021), while an intrathecal injection of anti-IL-6 neutralizing antibody can significantly reduce these pain-related behaviors (Zhou et al., 2016a)

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