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In addition, TB treatment induced significant epigenetic remodeling in preneoplastic livers, including moderate hyperacetylation of histone H3K9 and H3K18 and robust hyperacetylation of H4K16 [107]

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GLP-1 RAs, acting via MC4R -independent pathways in the brainstem and hypothalamus [62,63] , may address this persistent hyperphagic drive that surgery alone cannot overcome

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