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As male mice more robustly develop symptoms of metabolic syndrome than female, only male Ctrl and KO mice were challenged with a 60% high fat diet (D12492, HFD, Research Diets, New Brunswick, USA) for 12 weeks, starting at the age of 5 weeks, before p53 ablation was facilitated by treating the mice with Tamoxifen (100 mg/kg via oral gavage for 5 consecutive days (Molekula group, Munich, Germany) followed by a 1 week wash out period

The dose is then gradually increased, typically in 2.5 mg increments, based on your goals and tolerance, up to a maximum of 15 mg weekly

doi:10.1159/000059404 Kristensen T, Vestergaard H, Mller MB

This article is intended for informational purposes only

Carnitine and adiponectin levels in breast cancer after radiotherapy