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White adipose tissue is the largest endocrine organ that secretes systemic pro-inflammatory adipokines and cytokines

How clinicians might think about this (risk vs benefit) GLP-1 receptor agonists have benefits that are not small: strong glucose lowering in many patients weight loss benefits in certain populations, cardiovascular risk reduction sometimes improved adherence compared to multiple daily pills because of weekly dosing options So for many patients, the benefit side of the equation is heavy

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