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They were initially developed to control blood sugar in diabetics, but researchers noticed something unexpected: they also triggered substantial weight loss and appeared to protect against heart attacks and strokes

Linear mixed-effects models (LMMs) were used to test for sex differences, with batch effects treated as a random variable

Improper storage is one of the most common reasons research compounds lose potency before a study even begins, so this step matters more than people expect

The mechanism: tirzepatide lowers insulin resistance, and high insulin secretion is regarded as a driver of follicle miniaturization, partly through stronger androgen signaling and more DHT production

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