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Vascular endothelial growth factor gene regulation and action in diabetic retinopathy

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These modifications enhance its half-life by increasing albumin binding and inhibiting degradation by DPP-4, allowing for once-weekly dosing

Notably, these biomarkers are not solely metabolic but also reflect chronic inflammatory and immunometabolic stress (for example, oxidative stress, impaired mitochondrial health and immunoendocrine signaling)