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A also stimulates the activation of NADPH oxidases (NOXs), integrin Iib-3, and ROS, promoting platelet adhesion, increasing levels of the endogenous inhibitors plasminogen activator inhibitor-1 and endothelin-1 (ET-1), and resulting in thrombosis, capillary constriction, and impaired blood flow [99, 181, 182]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Yao Q., Tan W., Bai F

Histone-lysine N-methyltransferase 2D (KMT2D, MLL4) is an important epigenetic regulator ( Mll4 epidermal-specific knockout mice and found that Mll4 deficiency in the epidermis impacts epidermal differentiation and disrupts skin homeostasis in mice