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A 2025 study directly challenged this in -cells, finding that cAMP/PKA/ERK signaling is diffusely distributed across the cell regardless of internalization kinetics, and that fast-internalizing agonists are paradoxically less efficient drivers of insulin secretion from perfused rat pancreata (Chen et al., 2025)

Major cardiovascular events occurred in 3.8% of the participants in oral semaglutide group and 4.8% in placebo group (HR: 0.79, CI: 0.57 to 1.11

In the atrial fibrillation (AFib) subanalysis, researchers examined the efficacy and safety of semaglutide in people with and without AFib within the STEP-HFpEF program and found that once weekly semaglutide (2.4 mg) was associated with even greater improvements in HF-related symptoms and physical limitations in those with vs