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These studies assessed the efficacy and safety of escalating weekly doses of tirzepatide from 5 mg to 15 mg over 12 weeks compared to placebo,188 and over 26 weeks compared to placebo or dulaglutide, selective GLP-1RAs.189 Subsequently, tirzepatide has been extensively investigated in the SURPASS program, a comprehensive development initiative targeting T2DM that is inadequately controlled by various glucose-lowering regimens, including lifestyle alone (SURPASS-1),190 metformin monotherapy (SURPASS-2),191 metformin with or without sodium-glucose co-transporter 2 inhibitors (SGLT2i) (SURPASS-3),192 combination therapy including metformin, SGLT2i, and sulfonylureas (SURPASS-4),193 insulin glargine with or without metformin (SURPASS-5),88 and insulin lispro with basal insulin (SURPASS-6).194 Across all SURPASS trials, tirzepatide demonstrated a dose-dependent reduction in HbA1c levels, which consistently exceeded the reductions observed with comparator treatments
We're taking a significant step forward in making these innovative brand-name treatments more accessible for millions of people who need them." Shares in GoodRx were up nearly 29% at the time of writing, while Novo Nordisk rose nearly 7%, partially helping to offset a steep decline since the start of the year.
I dont think this study should play any role in physicians recommending weight loss drugs to prevent macular degeneration
Central to the Ozempic litigation are the allegations against Novo Nordisk concerning the transparency and disclosure of potential side effects associated with their GLP-1 based drugs, used primarily for diabetes management and weight loss
