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Poria acid (PA) upregulated the expression of GPX4, SLC7A11, and HO-1 by increasing the level of GSH and activating NRF2 in a mouse IRI-AKI model, which inhibited the induction of ferroptosis and attenuated AKI [8, 110]
It is important to note that whilst these mechanisms are biologically plausible, the presence of a theoretical mechanism does not automatically translate to clinical efficacy
Pretreatment of RAW 264.7 macrophage cells with GHK-Cu has been shown to significantly decrease ROS levels induced by lipopolysaccharide (LPS), increase levels of SOD activities and total GSH, and decrease levels of TNF- and IL-6 production through the suppression of NF-B p65 and p38 MAPK signaling [22]
Copper, oxidative stress, and human health
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