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These results revealed that LA supplementation might enhance iron storage and promote iron turnover by upregulating Ferritin and FPN, therefore reducing iron accumulation, as shown in Figure 4

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As H 2 O 2 and superoxide (O 2 ) ions have been reported to have an inhibitory effect on SOD and catalase activities, respectively, the authors have suggested that riboflavin deficiency may lead to an overproduction of reactive oxygen species (obviously through a mechanism independent of the glutathione redox cycle) beyond the scavenging ability of SOD and catalase