This has happened before, at least twice, and when it has it has represented periods in time where anti-doping and regulators were scrambling to catch up to illegal drugs or substances that had become mainstream
A four-week hold is roughly the window needed for a step to reach steady state and for the gut to adapt to it, which is why escalating before the block is complete effectively means judging a dose you have not yet fully experienced
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I dont think pharma is necessarily incentivized to figure out the dosing in this population thats looking to use less medicine. Rybelsus, an Food and Drug Administration-approved oral GLP-1 drug, is approved to treat Type 2 diabetes but not weight loss