So you may get many of the systemic effects anyway, just with needles and a bigger bill
A 2025 IRB-approved pilot study published in PubMed reported no adverse effects following intravenous administration of 20mg in 2 healthy adults, with monitored biomarkers (heart, liver, kidneys, thyroid, and blood glucose) returning normal results
Anson, F., Thayumanavan, S
Hyaluronic acid has documented benefits for joint health, with a 2012 study in The Scientific World Journal showing oral hyaluronic acid improved joint function and reduced pain in osteoarthritis patients
For low doses like 2.5 mg (12.5 units) from a 20 mg/ml vial, a 0.3 ml syringe gives you much better precision than a full 1 ml syringe where those same 12.5 units occupy a tiny sliver of the barrel