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Therefore, the inhibitors developed for the C467 residue of ASCT2 boast the advantages of high specificity and high potency, which can effectively avoid the loss of competitive inhibition by substrate analog inhibitors due to high substrate concentration

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Another study demonstrated that while branched-chain amino acids (valine, leucine, and isoleucine) and taurine were significantly decreased, three metabolites of the kynurenine pathway, specifically 2-aminobenzoic acid, xanthurenic acid, and hydroxy picolinic acid were reported to be significantly upregulated in ESKD patients compared to CKD patients

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