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The critical dependence on copper is underscored by pathologies arising from its dysregulation

This proposed concept mirrors forward genetics, we know the external phenotype is melanoma, therefore doing a high throughput un-biased screen for serum biomarkers will reveal expression changes of biomarkers between healthy controls, disease-free patients, and melanoma patients, which will provide insights into key driver pathways regulating metastasis

These cells produce additional proinflammatory mediators, such as TNF-, IL-6, and ROS, further exacerbating liver inflammation and hepatocyte injury

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