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Given that obesity in adolescence is already associated with an increased risk of depression and suicidal ideation, and considering the rise in GLP-1 receptor agonist prescriptions since FDA approval in 2020, it was crucial to investigate whether this treatment impacts psychiatric outcomes

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In the current study, we confirmed that liver GLP-1R expression was downregulated in NAFLD patients compared with its expression in normal controls

Similarly, a sedentary lifestyle limits the metabolic benefits of weight loss and glycaemic improvement