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Both cause gastrointestinal symptoms as the most common adverse effects, but the specific pattern and severity can differ

In individuals with obesity and diabetes, the incretin effect is diminished, contributing to poor glucose tolerance

doi:10.1042/bj0910237

Small molecules and nanoparticles that are water-soluble are able to permeate the blood-brain barrier (BBB) by the process of paracellular passive diffusion, which involves sliding down an inverse concentration gradient across tight junctions

doi: 10.3389/fendo.2025.1708007 Received 18 September 2025 Revised 30 November 2025 Accepted 01 December 2025 Published 15 December 2025 Volume 16 - 2025 Edited by Dipak Kumar Sahoo, Iowa State University, United States Reviewed by Fernando Hinostroza, Universidad Catlica del Maule, Chile Anil Patani, Sankalchand Patel University, India Updates Copyright 2025 Park