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These include: Pregnant women: There is no data on its safety in pregnant women, so they are usually advised to avoid this supplement

387 Regarding PIK3CA -mutated advanced breast cancer, the SOLAR-1 study confirms the significant PFS benefit of alpelisib combined with fulvestrant in such patients

58,59 Increased market competition is anticipated, but further policy reforms to the patent system and regulatory frameworks could facilitate faster entry of generic alternatives, driving down costs

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