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Underlying mechanisms contributing to cardiovascular and renal protection are at least partially different between GLP-1RAs (mainly anti-atherogenic and vascular effects) and SGLT2is (mainly systemic and intrarenal hemodynamic changes)

GHK-Cu also modulates gene expressionupregulating genes associated with tissue repair while downregulating inflammatory and fibrotic pathways

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In the subcutaneous form, the 0.5 mg and 1 mg doses showed similar efficacy, demonstrating that lower doses may be feasible for many patients

It enhances blood sugar control by increasing insulin release when needed and reducing excess glucagon secretion