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At the same time, pro-inflammatory factors (TNF- and IL-1) were downregulated and anti-inflammatory factors (Arg-1 and IL-10) were upregulated due to SIN produced through the NF-B pathway, which decreased M1 macrophage levels and increased M2 macrophage levels

1,2,6,12 Dementia-like disease, including episodes of psychosis, is thought to be associated with more severe and chronic deficiency, although supporting evidence is poor

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