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DIAGNOSTIC CRITERIA Using Rome III diagnostic criteria, the disorder has been estimated to have an annual community prevalence of 0.2% to 1.0% [1, 2, 3]

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However, it is important to note that both THC and CBD have many CBR-independent or indirect signaling mechanisms that also contribute to their overall outcomes (Pertwee, 2008

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Athira Pharma (formerly M3 Biotechnology), the WSU spinout founded to commercialize Dihexa-derivative compounds, paid approximately $4 million in a False Claims Act settlement in January 2025 after a whistleblower exposed concealment of the research misconduct from federal grant agencies, and approximately $10 million in a separate class-action settlement to investors