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Twenty-four hours following the cessation of heroin administration, the mice were placed individually in a transparent plastic container with a diameter of 20 cm and a height of 30 cm

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[4] Similarly, SURPASS-4, which specifically enrolled patients at high cardiovascular risk, demonstrated a numerical reduction in MACE with tirzepatide compared to insulin glargine, suggesting potential cardiovascular benefit, though definitive conclusions await the dedicated outcomes trial

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