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These findings suggest that prolonged disease duration may serve as a predisposing factor for SIBO, whereas the absence of anti-topoisomerase-I antibodies may confer a protective effect in SSc patients [57]

In the case of TB, there is a very strong genetic basis of susceptibility to this bacterium, with resistance developing among the indigenous north American population after European colonization, owing to the high initial mortality and therefore rapid selection against susceptibility genes (Abel et al., 2018)

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