Clinical consequences of delayed gastric emptying with GLP-1 receptor agonists and tirzepatide, The Journal of Clinical Endocrinology & Metabolism 2025;110,(1)115
Drug Discov Today 21(5):802818 Hamilton A, Hlscher C (2009) Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system
In June 2021, the agency approved Wegovy (semaglutide 2.4 mg once weekly) for weight management in adults with a body mass index (BMI) of 30 kg/m or greater (obesity), or a BMI of 27 kg/m or greater (overweight) with at least one weight-related comorbidity such as hypertension, dyslipidemia, or obstructive sleep apnea
Early indications are that the launch should be more stable than the shortages that defined the early GLP-1 surge, with supply chains better prepared and, presumably, some degree of slack in production capacity
Teriparatide is already used clinically in some of these cases, and the preclinical evidence for BPC-157 specifically addressed bone defects that failed to heal in control animals
