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However, many patients have experienced severe and sometimes life-threatening side effects, including gastroparesis, pancreatitis, and vision problems

For a deeper look at what GLP-1 approval actually required, Meto's clinical overview of GLP-1 drugs provides useful context as does our recent piece on Foundayo (orforglipron), the first oral GLP-1 to reach approval

Beyond these individual cancers, the cohort analysis showed significantly lower rates of 10 OACs in GLP-1RA users compared with those on insulin

I feel great and have lots of energy

There was no significant difference between tirzepatide and semaglutide in the SURPASS-2 study at Week 40 in change in heart rate compared to baseline despite higher reduction in HbA1c, weight and SBP [18]