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Behavioural tests Mice were acclimated to the testing chambers for 3 successive days before the behavioural tests

Corsini EM, Weissferdt A, Pataer A, Zhou N, Antonoff MB, Hofstetter WL , Mehran RJ, Rajaram R, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Cascone T, Heymach JV, Swisher SG, Sepesi B

Body weight loss had an estimated 0.5% mediation effect on the primary kidney outcome, a 33.4% mediation effect on CV events and a 25.6% mediation effect on all-cause death

FIGURE 3 Visceral fat is not only a storage depot but also acts as an endocrine organ, releasing a variety of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1) (64)