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Ferrulli and colleagues ran a randomized, sham-controlled trial of 33 adults with obesity: deep TMS targeting the PFC and insula for five weeks produced significant weight loss that persisted at 12-month follow-up [16]
Patients who dont deliberately eat enough protein can lose muscle alongside fat, which slows metabolism and makes it harder to sustain loss over time
Maintain adequate nutrition despite suppressed appetite
It's a long-term commitment, not a quick fix
Retatrutide, a triple agonist in Phase 3 clinical trials, produced average weight loss of 24 percent at 48 weeks in Phase 2 data (Jastreboff et al., NEJM , 2023)
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