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The condition involves dysregulation of neurotransmitters, inflammatory mediators, and stress response systems, producing a constellation of symptoms extending far beyond pain to include crushing fatigue, unrefreshing sleep, cognitive dysfunction known as fibro fog, and heightened sensitivity to temperature, sound, and light

For in vivo pharmacokinetic analysis, male Sprague-Dawley rats weighing 250 g were cannulated in the right jugular vein

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By day three to five of multi-dose use after multiple needle punctures have introduced skin-flora organisms through the rubber stopper microbial counts begin to climb