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Clinical trials have shown semaglutide use can lead to weight reductions of 14.9% to 17.4% in individuals without diabetes (Wilding et al., 2023)

Federal Drug Administration (FDA-a)

The microdosing protocol uses lower doses of semaglutide ($79.99 per month) or tirzepatide ($99.99 per month) for men who need to lose a smaller amount of weight or want to maintain results from a previous treatment phase

28 GilmanC.PerryT.FurukawaK.GriegN.EganJ.MattsonM

In that study, exendin-4 not only ameliorated albuminuria but conferred kidney structural benefits including reduced glomerular hypertrophy and mesangial matrix expansion in the absence of an effect on body weight, blood pressure, or circulating glucose concentrations