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In recent years, our understanding of MCAS has grown significantly, and diagnostic criteria have evolved accordingly

Tirzepatide: A Dual GLP-1 and GIP Agonist Tirzepatide, on the other hand, is a dual agonist , meaning it mimics the action of two natural gut hormones: GLP-1 and GIP (Glucose-dependent Insulinotropic Polypeptide)

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Activation leads to: Increased sebum production , may contribute to acne in some research subjects Changes in sebum composition Pheromone secretion (in animal models) This is a less important mechanism with Melanotan II, but contributes to its non-selective profile

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