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Additional information Peer review information Nature thanks Michael Murphy, Tracey Rouault and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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277 Scavenger receptor class B type I (SRBI) plays a crucial role in promoting cholesterol efflux from cells and clearing plasma cholesterol, while SRBI deficiency results in disrupted cholesterol metabolism, hyperlipidemia, and subsequent ferroptosis via the HIF-1/TFR1 pathway