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Human cytomegalovirus also affects astrocytes and reduces astrocytic production of thrombospondins, 261 such affecting synaptogenesis, and suppresses astrocytic expression of glutamate transporters, 262 thus decreasing neuroprotection again excitotoxic damage

14 Clinical Consequences of First-Pass Metabolism The first-pass effect can dramatically reduce the oral bioavailability of a drug

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To understand how GLP-1 agonists function, youll need to know a thing or two about the hormone theyre meant to resemble