Consequently, the principal endpoint was not achieved
Specific ECM-based biomarkers indicative of MMP-2 activity, such as C1M (MMP-2, 9, 13 mediated degradation of type I collagen) and C4M (MMP-2, 9, 12 mediated degradation of type IV collagen), are significantly elevated in higher Hurley stages (II and III) of HS and show a moderate-strong correlation with the Hidradenitis Suppurativa Score (HSS), a classification system of the disease severity, reflecting ongoing dermis degradation and disease activity [104, 105] (Table 1, Fig
For specific side effect management strategies, these resources cover each issue in depth
However, its potential for weight loss has gained significant attention
Kim DW, Tan EY, Jin Y et al , Effects of imatinib mesylate on the pharmacokinetics of paracetamol (acetaminophen) in Korean patients with chronic myelogenous leukaemia