is semaglutide hard on your kidneys Novo unveils full results from its GLP-1 trial in CKD Semaglutide Protects Kidneys: New CKD

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doi: 10.1016/j.jhazmat.2023.131595

42.9% of GLP-1 users reported losing less than 20 pounds

These outcomes are largely anecdotal and may stem from the peptides influence on melanocortin receptors, which could affect neurotransmitter activity

Conversely, persistent appetite, continued craving, or weight regain may indicate that psychological, behavioural, environmental, or treatment-exposure factors are overriding satiety-related effects, especially because weight regain can occur after treatment withdrawal or interruption (95)