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However, patients taking multiple antihypertensive medications should have their blood pressure monitored regularly, as excessive lowering could potentially cause symptomatic hypotension, particularly in elderly patients or those with autonomic dysfunction

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

EMBO J 16:48064816 Wirtz M, Hell R (2007) Dominant-negative modification reveals the regulatory function of the multimeric cysteine synthase protein complex in transgenic tobacco

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Tuci et al., 2025)