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The TCF7L2 Gene: Your GLP-1 Regulator The TCF7L2 gene is a GLP-1 regulator and its important because it: Directly regulates the production and secretion of GLP-1 Influences how well GLP-1 can stimulate insulin release Its strongly linked to type 2 diabetes risk (the strongest genetic risk factor identified!) When you have certain variants of TCF7L2, your body produces less GLP-1 and responds more weakly to the GLP-1 you do produce

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Semaglutide is also the active ingredient in Wegovy, which is FDA-approved for weight loss and long-term weight management in those with obesity or overweight