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These variants are pathway-level and do not predict response to any specific compound, yet they frame the biology your clinician is prescribing into

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It promotes the secretion of mucin Muc2 by goblet cells and stimulates Paneth cells to release lysozyme and antimicrobial peptides, collectively enhancing the mucosal barrier

Dingxi Liu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers