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PMID 22872058

Specific pathways affected include TGF-beta superfamily signaling, Wnt signaling, antioxidant defense (including superoxide dismutase, glutathione S-transferases, and thioredoxin reductase), and DNA repair mechanisms

instead, insulin is mainly cleared by the liver (44)

Study of the anticancer potential of plant extracts using liver tumor microphysiological system

Abstract Background: The widespread clinical use of immune checkpoint inhibitors (ICIs) in oncology has been accompanied by an increased incidence of immune-related adverse events (irAEs)

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