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By simultaneously activating these receptors, retatrutide optimises: Weight loss Insulin secretion Glucose metabolism Thermogenic processes Consequently, retatrutide significantly outperforms peptides that target fewer metabolic pathways

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

However, a 2024 meta-analysis of 10 RCTs (n=413) found that benefits were confined to adjunctive therapy at doses of 2,000 mg/day or higher, with no superiority over placebo for monotherapy [34]