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518,519 In addition, in pediatric UC patients, when treated with low-dose or high-dose vedolizumab on day 1 and at weeks 2, 6, and 14, respectively, significant efficacy was similarly demonstrated

This allows researchers to test a range of doses on a smaller cohort, identifying the minimum effective dose and any potential adverse effects before committing to a larger, more resource-intensive study

doi: 10.1016/j.bbagen.2012.09.018

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