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We also found a significant reduction in the levels of tumor promoter GPs at the end of 4th week during 4-week intermittent fasting (POLK, CD109, CAMP, NIFK, SRGN), and 1 week after 4-week intermittent fasting (CAMP, PLAC1) compared with the levels before 4-week intermittent fasting

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Specifically, rapamycin, a representative mTOR inhibitor, significantly inhibits IL-2-mediated T-cell proliferation by blocking the cell cycle transition from the G1 phase to the S phase, thereby attenuating excessive immune responses, especially in AIDs and transplant rejection (220222)