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Nutr Cancer 2009;61:437-446

Methylcobalamin B12 is also indicated in those with pernicious anemia, diabetes, neuropathy, heart disease, circadian rhythm sleep disorders, memory loss, depression, fatigue, AIDS, inflammatory bowel disease (IBD), Lyme disease, osteoporosis, tendonitis, psychiatric disorders, Alzheimers disease, liver and kidney disease, and asthma

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1) Patients with hypersensitivity reaction to thioctic acid (a-lipoic acid) and components of this drug 2) Children and adolescents (less clinical experience) 3