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Their primary effects include: Glucose-dependent insulin secretion from pancreatic beta cells Suppression of glucagon release from alpha cells Delayed gastric emptying , promoting satiety Central appetite suppression via hypothalamic pathways Reduced energy intake through decreased appetite and earlier satiety These medications produce substantial weight losstypically 10-15% of body weight with semaglutide and up to 20% with tirzepatideprimarily through reduced caloric intake

doi:10.3390/antiox11010154 Sp N, Kang DY, Kim DH, et al

proposed that GLP-1 RAs might exert a direct effect on -cells, as the inhibition was not reversed by the insulin receptor antagonist or the SSTR2 antagonist [52]

A categorical shift from near-zero to clinically meaningful

But the numbers are still small