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Conformational changes in tyrosine 11 of neurotensin are required to activate the neurotensin receptor 1

Abstract Glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide 1 receptor (GLP-1R) are expressed in the central nervous system (CNS) and regulate food intake

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My question: given my MS stability but significant metabolic risk factors (obesity, pre-diabetes, cholesterol, thyroid), do you think a GLP-1 agonist (such as tirzepatide or semaglutide) would be a reasonable option for me

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