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Patients with low RGC withheld their GLP-1s for 8 days [510], while patients with high RGC withheld for 6 days [39] ( P = .003)

In SURMOUNT-4, people who stopped Mounjaro suddenly and switched to a placebo regained much of the weight they had lost, while those who continued taking it lost more

Activation of nicotinic acetylcholine receptors can suppress the downstream mechanisms of excitotoxicity, including intracellular Ca 2+ overload, increased ROS, and mitochondrial energy metabolism disorders