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Mefenamic acid (a 2,3-dimethyl derivative), a widely used NSAIDs and known AKR1Cs inhibitor with an IC 50 value of 0.3 M against AKR1C3, was easy to synthesize and inhibited AKR1C enzymes but not COX-1 or COX-2 in the pattern of competitive inhibitors of AKR1C enzymes (Penning et al., 2006

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