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[10] Other uncommon adverse effects reported with very high doses include dermatological lesions (photosensitivity and skin rash), gastrointestinal upset, and in some cases dependency syndromes (e.g

The ability of eNOS produced NO to prevent platelet adhesion and aggregation reduces the propensity for the development of abnormal fibrin clots (thrombi) and, therefore, will contribute to a reduced potential for the development of atherosclerosis

Having a higher weight or other underlying conditions such as diabetes can lead to negative effects on muscles, tendons, and joints

10.1016/S0140-6736(02)07952-7 118 ZhangY.KahngM

Obesity-associated oxidative stress increases glutathione (GSH) turnover, potentially elevating demand for amino acid precursors required for antioxidant defense [73, 74]