Researchers administering cisplatin (5 mg/kg) to rats found marked toxic effects related to the dosage and timing in relation to their sexual cycle ( 4 Effective strategies to prevent the POF induced by cisplatin Due to the significant renal toxicity of cisplatin therapy, pre-treatment hydration therapy must be initiated before the treatment ( For gastrointestinal toxicity causing nausea and vomiting, antiemesis drugs can be used before the medication, a four-drug combination regimen consisting of NK1 receptor antagonist, 5-HT3 receptor antagonist, dexamethasone, and olanzapine has been recommended by the American Society of Clinical Oncology guidelines ( For hematological toxicity, granulocyte colony stimulating factor (G-CSF), recombinant human platelet growth factor, erythropoietin (EPO) and other drugs can be used to treat the symptoms, the chemotherapy doses can be adjusted, or blood transfusions may be required ( The neurotoxicity caused by cisplatin treatment cannot be avoided
Rousta et al., 2022)
The staff went beyond their job from the reception, to the doctor who assisted me until I paid , they are all professional
Unfortunately, the widely held belief that it is safe for pediatric use is based on numerous clinical studies that assume that the liver is the target of drug toxicity [5]
10.1016/j.sjbs.2021.12.060 41 MatsosA.LoomesM.ZhouI.MacmillanE.SabelI.RotziokosE.et al (2017)
