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Research has documented MT-1s anti-inflammatory effects across skin cell models and systemic inflammatory models , characterising NF-B suppression, reduced TNF-alpha and IL-6 production, neutrophil activation inhibition, and anti-inflammatory effects in ischaemia-reperfusion and colitis models through MC1R-cAMP-mediated mechanisms

Vitamin B6 is involved in the production of serotonin, dopamine and GABA crucial neurotransmitters that regulate mood, sleep, and other functions

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Patients with depression carrying the D/D variant of the ACE gene show considerably greater activation of the HPA axis (65)