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history of or active ischemic, hemorrhagic or anatomical neurovascular disease, including transient ischemic attack, cerebrovascular accident, arteriovenous malformation or brain aneurysm, peripheral vascular disease such as deep vein thrombosis/pulmonary embolism, chronic venous insufficiency, claudication or lymphedema

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Thus, studies conducted on animals have demonstrated that inhibition of the endogenous methylation demand by creatine supplementation can reduce Hcy levels, but these results have not been reproduced in human subjects

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